Article
Novel Primary Human Cancer Stem-Like Cell Populations from Non-Small Cell Lung Cancer: Inhibition of Cell Survival by Targeting NF-κB and MYC Signaling.
Cells - 27 Apr 2021
Windmöller Beatrice A, Beshay Morris, Helweg Laureen P, Flottmann Clara, Beermann Miriam, Förster Christine, Wilkens Ludwig, Greiner Johannes F W, Kaltschmidt Christian, Kaltschmidt Barbara
Abstract excerpt
There is growing evidence that cancer stem cells (CSCs), a small subpopulation of self-renewal cancer cells, are responsible for tumor growth, treatment resistance, and cancer relapse and are thus of enormous clinical interest. Here, we aimed to isolate new CSC-like cells derived from human primary non-small cell lung cancer (NSCLC) specimens and to analyze the influence of different inhibitors of NF-κB and MYC...
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