Article
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline.
Nature - 1 May 2020
Montagne Axel, Nation Daniel A, Sagare Abhay P, Barisano Giuseppe, Sweeney Melanie D, Chakhoyan Ararat, Pachicano Maricarmen, Joe Elizabeth, Nelson Amy R, D'Orazio Lina M, Buennagel David P, Harrington Michael G, Benzinger Tammie L S, Fagan Anne M, Ringman John M, Schneider Lon S, Morris John C, Reiman Eric M, Caselli Richard J, Chui Helena C, Tcw Julia, Chen Yining, Pa Judy, Conti Peter S, Law Meng, Toga Arthur W, Zlokovic Berislav V
Abstract excerpt
Vascular contributions to dementia and Alzheimer's disease are increasingly recognized1-6. Recent studies have suggested that breakdown of the blood-brain barrier (BBB) is an early biomarker of human cognitive dysfunction7, including the early clinical stages of Alzheimer's disease5,8-10. The E4 variant of apolipoprotein E (APOE4), the main susceptibility gene for Alzheimer's disease11-14, leads to accelerated...
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