Article
Immunohistochemistry as a reliable method for detection of BRAF-V600E mutation in melanoma: a systematic review and meta-analysis of current published literature.
The Journal of surgical research - 15 Jun 2016
Anwar Muhammad Ahmed Farooq, Murad Fadi, Dawson Erin, Abd Elmageed Zakaria Y, Tsumagari Koji, Kandil Emad
Abstract excerpt
BACKGROUND: The BRAF-V600E mutation is associated with tumor aggressiveness and poor prognosis in melanoma patients. Identification of this mutation is clinically important as we now have Food and Drug Administration-approved targeted therapies, such as BRAF and MEK inhibitors, which have been sh...
Topics
- Biomarkers, Tumor
- DNA Mutational Analysis
- Humans
- Immunohistochemistry
- Melanoma
- Models, Statistical
- Mutation
- Polymerase Chain Reaction
- Proto-Oncogene Proteins B-raf
- Sensitivity and Specificity
- Skin Neoplasms