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BRAFp.V600E, p.V600K, and p.V600R Mutations in Malignant Melanoma: Do They Also Differ in Immunohistochemical Assessment and Clinical Features?

Applied immunohistochemistry & molecular morphology : AIMM - 1 Jan 2016

Ponti Giovanni, Tomasi Aldo, Maiorana Antonio, Ruini Cristel, Maccaferri Monia, Cesinaro Anna M, Depenni Roberta, Manni Paola, Gelsomino Fabio, Giusti Francesca, Garagnani Lorella, Pellacani Giovanni

Abstract excerpt

INTRODUCTION: Although the detection of BRAF p.V600E mutation by immunohistochemistry was clearly described in melanoma, discordant evidences were reported for the detection of p.V600K and p.V600R mutations. The aim of the study was to evaluate the efficacy of BRAFp.V600E, p.V600K, and p.V600R detection by immunohistochemistry in melanoma. MATERIALS AND METHODS: Immunohistochemistry with VE1 antibody was...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 26633701
DOI: 10.1097/PAI.0000000000000153

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BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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