Article
A comparison of immunohistochemical and molecular methods used for analyzing the BRAF V600E gene mutation in malignant melanoma in Taiwan.
Asia-Pacific journal of clinical oncology - 1 Dec 2016
Huang Wen-Kuan, Kuo Tseng-Tong, Wu Chiao-En, Cheng Hsin-Yi, Hsieh Chia-Hsun, Hsieh Jia-Juan, Shen Yung-Chi, Hou Ming-Mo, Hsu Todd, Chang John Wen-Cheng
Abstract excerpt
AIMS: The BRAF V600 mutation has been shown to be clinically meaningful in terms of both the prognosis and sensitivity of BRAF inhibitors in patients with metastatic melanoma. Recently, a BRAF V600E mutation-specific antibody, VE1, was generated for the detection of tumors bearing BRAF V600E muta...
Topics
- Adult
- Biomarkers, Tumor
- DNA Mutational Analysis
- Female
- Humans
- Immunohistochemistry
- Lymph Nodes
- Lymphatic Metastasis
- Male
- Melanoma
- Middle Aged
- Mutation
- Prognosis
- Proto-Oncogene Proteins B-raf
- Sensitivity and Specificity