Article
Immunohistochemistry as a quick screening method for clinical detection of BRAF(V600E) mutation in melanoma patients.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jun 2014
Chen Qiongrong, Xia Chunjiao, Deng Yunte, Wang Mingwei, Luo Ping, Wu Changming, Yue Junqiu, Fang Na, Wang Manxiang, Wei Shaozhong
Abstract excerpt
With the increased uses of targeted therapeutics, diagnostic detection of target mutations becomes essential for the effective clinical applications of targeted therapeutics. Currently, there are two types of methods detecting target mutations in clinics: one is based on DNA sequence and the other uses the newly developed mutation-specific antibodies recognizing mutated proteins. Each method has its own...
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