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Article

Prospective immunohistochemical analysis of BRAF V600E mutation in melanoma.

Human pathology - 1 Feb 2015

Thiel Alexandra, Moza Monica, Kytölä Soili, Orpana Arto, Jahkola Tiina, Hernberg Micaela, Virolainen Susanna, Ristimäki Ari

Abstract excerpt

The v-raf murine sarcoma viral oncogene homolog B1 (BRAF) V600E mutation is the most common activating genetic alteration of this oncogene and a predictive marker for the therapeutic use of BRAF inhibitors in melanoma. Our aim was to evaluate the performance of BRAF V600E mutation-specific monoclonal antibody (VE1) in a prospective diagnostic setting of melanoma patients (n = 102). All 41 cases (40.2%) that...

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Source

Identifiers

PMID: 25442222
DOI: 10.1016/j.humpath.2014.08.018

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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