Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunohistochemistry is highly sensitive and specific for the detection of V600E BRAF mutation in melanoma.

The American journal of surgical pathology - 1 Jan 2013

Long Georgina V, Wilmott James S, Capper David, Preusser Matthias, Zhang Yuxiao E, Thompson John F, Kefford Richard F, von Deimling Andreas, Scolyer Richard A

Abstract excerpt

This study investigated the sensitivity and specificity of immunohistochemical (IHC) analysis using an anti-BRAF antibody to detect the presence of the BRAF V600E mutation in patients with metastatic melanoma. A total of 100 patients with American Joint Committee on Cancer stage IIIC unresectable or stage IV melanoma and who underwent tumor DNA BRAF mutation testing were selected. Paraffin-embedded,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Immunohistochemistry

Share to Mutation

Share to Reproducibility of Results

Share to Sensitivity and Specificity

Share to Skin Neoplasms

Source

Identifiers

PMID: 23026937
DOI: 10.1097/PAS.0b013e31826485c0

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunohistochemistry is highly sensitive and specific for the detection of V600E BRAF mutation in melanoma.PMID 23026937Read ↗

[Utility and evaluation of immunohistochemical detection of BRAF V600E mutation in melanoma].Semantic proximity Read ↗

Immunohistochemistry as a reliable method for detection of BRAF-V600E mutation in melanoma: a systematic review and meta-analysis of current published literature.Semantic proximity Read ↗

A comparison of immunohistochemical and molecular methods used for analyzing the BRAF V600E gene mutation in malignant melanoma in Taiwan.Semantic proximity Read ↗

Prospective immunohistochemical analysis of BRAF V600E mutation in melanoma.Semantic proximity Read ↗

BRAF V600E mutation-specific antibody: A review.Semantic proximity Read ↗

Immunohistochemical detection of the BRAF V600E mutation in melanoma patients with monoclonal antibody VE1.Semantic proximity Read ↗

A UK feasibility and validation study of the VE1 monoclonal antibody immunohistochemistry stain for BRAF-V600E mutations in metastatic melanoma.Semantic proximity Read ↗

Immunohistochemistry with a mutation-specific monoclonal antibody as a screening tool for the BRAFV600E mutational status in primary cutaneous malignant melanoma.Semantic proximity Read ↗

BRAF V600 mutation detection in melanoma: a comparison of two laboratory testing methods.Semantic proximity Read ↗

BRAFp.V600E, p.V600K, and p.V600R Mutations in Malignant Melanoma: Do They Also Differ in Immunohistochemical Assessment and Clinical Features?Semantic proximity Read ↗

BRAFV600E protein expression in primary cutaneous malignant melanomas and paired metastases.Semantic proximity Read ↗

Immunohistochemistry as a quick screening method for clinical detection of BRAF(V600E) mutation in melanoma patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.