Article
Immunohistochemistry is highly sensitive and specific for the detection of V600E BRAF mutation in melanoma.
The American journal of surgical pathology - 1 Jan 2013
Long Georgina V, Wilmott James S, Capper David, Preusser Matthias, Zhang Yuxiao E, Thompson John F, Kefford Richard F, von Deimling Andreas, Scolyer Richard A
Abstract excerpt
This study investigated the sensitivity and specificity of immunohistochemical (IHC) analysis using an anti-BRAF antibody to detect the presence of the BRAF V600E mutation in patients with metastatic melanoma. A total of 100 patients with American Joint Committee on Cancer stage IIIC unresectable...
Topics
- Antibodies, Monoclonal
- Biomarkers, Tumor
- DNA Mutational Analysis
- Humans
- Immunohistochemistry
- Melanoma
- Mutation
- Neoplasm Staging
- Predictive Value of Tests
- Proto-Oncogene Proteins B-raf
- Reproducibility of Results
- Sensitivity and Specificity
- Skin Neoplasms