BRAF V600 mutation detection in melanoma: a comparison of two laboratory testing methods.

doi:10.1136/jclinpath-2017-204367

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Article

BRAF V600 mutation detection in melanoma: a comparison of two laboratory testing methods.

Journal of clinical pathology - 1 Nov 2017

O'Brien Odharnaith, Lyons Tomas, Murphy Sandra, Feeley Linda, Power Derek, Heffron Cynthia C B B

Abstract excerpt

AIMS: The assessment of B-raf proto-oncogene, serine/threonine kinase (BRAF) gene status is now standard practice in patients diagnosed with metastatic melanoma with its presence predicting a clinical response to treatment with BRAF inhibitors. The gold standard in determining BRAF status is curr...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
DNA Mutational Analysis
Genetic Predisposition to Disease
Humans
Immunohistochemistry
Ireland
Melanoma
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Mutation Rate

Phenotype

Polymerase Chain Reaction

Predictive Value of Tests

Proto-Oncogene Mas

Source

Open in PubMed

Identifiers

PMID: 28424234
DOI: 10.1136/jclinpath-2017-204367

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-28424234-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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