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Androgen-induced gene 1–associated cholesterol metabolism correlates with immune suppression in pancreatic ductal adenocarcinoma liver metastasis

2026-04-23

Abstract excerpt

<title>Abstract</title> <p> This study aims to investigate the role of androgen-induced gene 1 (AIG1) in linking cholesterol metabolism to immune remodeling during pancreatic ductal adenocarcinoma (PDAC) liver metastasis. By integrating scRNA-seq data from 199 human samples across 12 cohorts, we identified AIG1 as a gene enriched in basal-like tumor cells and further amplified during PDAC liver metastasis. Notab...

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Literature Corpus work
9b361761-0b15-5bc9-b3fe-72b369c37f59
DOI
10.21203/rs.3.rs-9264668/v1
Open publication

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Androgen-induced gene 1–associated cholesterol metabolism correlates with immune suppression in pancreatic ductal adenocarcinoma liver metastasisDOI 10.21203/rs.3.rs-9264668/v1
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