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Article

Genetic ablation of FASN attenuates the invasive potential of prostate cancer driven by Pten loss

9 Nov 2020

Abstract excerpt

Loss of the tumor suppressor gene Pten in murine prostate recapitulates human carcinogenesis and causes stromal proliferation surrounding murine prostate intraepithelial neoplasia (mPIN), which is reactive to microinvasion. In turn, invasion has been shown to be regulated in part by de novo fatty acid synthesis in prostate cancer. We therefore investigated the effects of genetic ablation of Fasn on invasive...

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PMID: 33166087
DOI: 10.1002/path.5587

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