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MBTPS2 acts as a regulator of lipogenesis and cholesterol synthesis through SREBP signalling in prostate cancer

29 Mar 2023

Abstract excerpt

BACKGROUND: Prostate cancer is the most common cancer in men in the developed world, with most deaths caused by advanced and metastatic disease which has no curative options. Here, we identified Mbtps2 alteration to be associated with metastatic disease in an unbiased in vivo screen and demonstrated its regulation of fatty acid and cholesterol metabolism. METHODS: murine prostate. MBTPS2 was knocked down by siRNA...

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Share to Cancer, Lipids, and Metabolism
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PMID: 36991255
DOI: 10.1038/s41416-023-02237-7

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