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Article

Dysregulation of Cholesterol Homeostasis in Human Prostate Cancer through Loss of <i>ABCA1</i>

11 Dec 2012

Abstract excerpt

Recent epidemiologic data show that low serum cholesterol level as well as statin use is associated with a decreased risk of developing aggressive or advanced prostate cancer, suggesting a role for cholesterol in aggressive prostate cancer development. Intracellular cholesterol promotes prostate cancer progression as a substrate for de novo androgen synthesis and through regulation of AKT signaling. By conducting...

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PMID: 23233737
DOI: 10.1158/0008-5472.can-12-3128

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