Article
A common variant on chromosome 9p21 affects the risk of myocardial infarction.
Science (New York, N.Y.) - 8 Jun 2007
Helgadottir Anna, Thorleifsson Gudmar, Manolescu Andrei, Gretarsdottir Solveig, Blondal Thorarinn, Jonasdottir Aslaug, Jonasdottir Adalbjorg, Sigurdsson Asgeir, Baker Adam, Palsson Arnar, Masson Gisli, Gudbjartsson Daniel F, Magnusson Kristinn P, Andersen Karl, Levey Allan I, Backman Valgerdur M, Matthiasdottir Sigurborg, Jonsdottir Thorbjorg, Palsson Stefan, Einarsdottir Helga, Gunnarsdottir Steinunn, Gylfason Arnaldur, Vaccarino Viola, Hooper W Craig, Reilly Muredach P, Granger Christopher B, Austin Harland, Rader Daniel J, Shah Svati H, Quyyumi Arshed A, Gulcher Jeffrey R, Thorgeirsson Gudmundur, Thorsteinsdottir Unnur, Kong Augustine, Stefansson Kari
Abstract excerpt
The global endemic of cardiovascular diseases calls for improved risk assessment and treatment. Here, we describe an association between myocardial infarction (MI) and a common sequence variant on chromosome 9p21. This study included a total of 4587 cases and 12,767 controls. The identified variant, adjacent to the tumor suppressor genes CDKN2A and CDKN2B, was associated with the disease with high significance....
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