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Article

Evaluation of X Chromosome Inactivation with Respect to HLA Genetic Susceptibility in Rheumatoid Arthritis and Systemic Sclerosis.

PloS one - 1 Jan 2016

Kanaan Sami B, Onat Onur E, Balandraud Nathalie, Martin Gabriel V, Nelson J Lee, Azzouz Doua F, Auger Isabelle, Arnoux Fanny, Martin Marielle, Roudier Jean, Ozcelik Tayfun, Lambert Nathalie C

Abstract excerpt

BACKGROUND: Autoimmune diseases, including rheumatoid arthritis (RA) and systemic sclerosis (SSc) are characterized by a strong genetic susceptibility from the Human Leucocyte Antigen (HLA) locus. Additionally, disorders of epigenetic processes, in particular non-random X chromosome inactivation (XCI), have been reported in many female-predominant autoimmune diseases. Here we test the hypothesis that women with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Leukocytes, Mononuclear

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Source

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Identifiers

PMID: 27355582
DOI: 10.1371/journal.pone.0158550
PMCID: PMC4927113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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