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Article

Skewed X chromosome inactivation in blood cells of women with scleroderma

1 May 2005

Abstract excerpt

OBJECTIVE: Scleroderma (SSc) is an autoimmune disease of unknown etiology. The disease is 3-8 times more frequent in women than in men. The role of X chromosome inactivation (XCI) in the predisposition of women to autoimmunity has been questioned. Until now this has not been illustrated experimentally. This study was undertaken to test the hypothesis that disturbances in XCI mosaicism may be involved in the...

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Identifiers

PMID: 15880831
DOI: 10.1002/art.21026

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