Article
Skewing of X chromosome inactivation in autoimmunity.
Autoimmunity - 1 May 2008
Invernizzi Pietro, Pasini Simone, Selmi Carlo, Miozzo Monica, Podda Mauro
Abstract excerpt
Approximately 5% of the population in Western countries is affected by autoimmune diseases (AID), with a significantly higher prevalence in women. Genetic factors are known to be crucial determinants of susceptibility as shown by family and twin studies, although no specific genes predisposing women to autoimmunity have been identified thus far. Several studies indicate that X chromosome abnormalities, such as...
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