Increased frequency of extremely skewed X chromosome inactivation in juvenile idiopathic arthritis.

doi:10.1002/art.24956

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Article

Increased frequency of extremely skewed X chromosome inactivation in juvenile idiopathic arthritis.

Arthritis and rheumatism - 1 Nov 2009

Uz Elif, Mustafa Chigdem, Topaloglu Rezan, Bilginer Yelda, Dursun Ali, Kasapcopur Ozgur, Ozen Seza, Bakkaloglu Aysin, Ozcelik Tayfun

Abstract excerpt

OBJECTIVE: Juvenile idiopathic arthritis (JIA) is a childhood rheumatic disease of unknown etiology. Two subgroups of JIA, i.e., oligoarticular and polyarticular, are thought to have an autoimmune component, and show a higher female:male ratio. Skewed X chromosome inactivation (XCI) has previously been shown to be associated with scleroderma and autoimmune thyroiditis, 2 autoimmune disorders occurring...

Topics

Adolescent
Arthritis, Juvenile
Case-Control Studies
Child
Child, Preschool
Chromosomes, Human, X
Female
Genetic Predisposition to Disease
Genotype
Heterozygote
Humans
Mutation
Receptors, Androgen
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 19877028
DOI: 10.1002/art.24956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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X Chromosome Inactivation