Article
X chromosome gene methylation in peripheral lymphocytes from monozygotic twins discordant for scleroderma.
Clinical and experimental immunology - 1 Sept 2012
Selmi C, Feghali-Bostwick C A, Lleo A, Lombardi S A, De Santis M, Cavaciocchi F, Zammataro L, Mitchell M M, Lasalle J M, Medsger T, Gershwin M E
Abstract excerpt
Scleroderma (SSc) is a rare connective tissue disease characterized by fibrosis, microvasculopathy and autoimmune features. The role of genetics is limited in SSc, as suggested by similar concordance rates in monozygotic and dizygotic twin pairs, while environmental factors may act through epigenetic changes, as demonstrated for specific genes. Further, sex chromosome changes have been reported in SSc and may...
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