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Article

Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseases.

Arthritis research & therapy - 1 Jan 2009

Chabchoub Ghazi, Uz Elif, Maalej Abdellatif, Mustafa Chigdem A, Rebai Ahmed, Mnif Mouna, Bahloul Zouheir, Farid Nadir R, Ozcelik Tayfun, Ayadi Hammadi

Abstract excerpt

INTRODUCTION: The majority of autoimmune diseases such as rheumatoid arthritis (RA) and autoimmune thyroid diseases (AITDs) are characterized by a striking female predominance superimposed on a predisposing genetic background. The role of extremely skewed X-chromosome inactivation (XCI) has been questioned in the pathogenesis of several autoimmune diseases. METHODS: We examined XCI profiles of females affected...

Topics

Adult
Arthritis, Rheumatoid
Autoantibodies
Autoimmune Diseases
Chromosomes, Human, X
Enzyme-Linked Immunosorbent Assay
Female
Fluorescent Antibody Technique
Genetic Predisposition to Disease
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Polymerase Chain Reaction

Thyroid Diseases

Tunisia

X Chromosome Inactivation

Source

Open in PubMed Open full text

Identifiers

PMID: 19589151
DOI: 10.1186/ar2759
PMCID: PMC2745787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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