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Article

Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseases.

Arthritis research & therapy - 1 Jan 2009

Chabchoub Ghazi, Uz Elif, Maalej Abdellatif, Mustafa Chigdem A, Rebai Ahmed, Mnif Mouna, Bahloul Zouheir, Farid Nadir R, Ozcelik Tayfun, Ayadi Hammadi

Abstract excerpt

INTRODUCTION: The majority of autoimmune diseases such as rheumatoid arthritis (RA) and autoimmune thyroid diseases (AITDs) are characterized by a striking female predominance superimposed on a predisposing genetic background. The role of extremely skewed X-chromosome inactivation (XCI) has been questioned in the pathogenesis of several autoimmune diseases. METHODS: We examined XCI profiles of females affected...

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Identifiers

PMID: 19589151
DOI: 10.1186/ar2759
PMCID: PMC2745787

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