Article
High frequency of skewed X-chromosome inactivation in females with autoimmune thyroid disease: a possible explanation for the female predisposition to thyroid autoimmunity.
The Journal of clinical endocrinology and metabolism - 1 Nov 2005
Brix Thomas Heiberg, Knudsen Gun Peggy S, Kristiansen Marianne, Kyvik Kirsten Ohm, Orstavik Karen Helene, Hegedüs Laszlo
Abstract excerpt
CONTEXT: Autoimmune thyroid diseases (AITD) comprise Graves' disease (GD) and Hashimoto's thyroiditis (HT). They are characterized by loss of immunological self-tolerance and female preponderance. Theoretically, X chromosome inactivation (XCI) and resultant tissue chimerism could offer an explanation for the female predisposition to AITD. AIM: Our aim was to examine whether skewed XCI is associated with AITD....
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