Article
The X chromosome and systemic sclerosis.
Current opinion in rheumatology - 1 Nov 2006
Selmi Carlo, Invernizzi Pietro, Gershwin M Eric
Abstract excerpt
PURPOSE OF REVIEW: Similar to the majority of autoimmune rheumatic diseases, systemic sclerosis is characterized by a striking female predominance superimposed on a predisposing genetic background. At least two genetic mechanisms have been proposed that play a role in susceptibility to systemic sclerosis; firstly the maintenance of immune tolerance via genes on the X chromosomes and, secondly, fetal...
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