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Article

The role of X-chromosome inactivation in female predisposition to autoimmunity.

Arthritis research - 1 Jan 2000

Chitnis S, Monteiro J, Glass D, Apatoff B, Salmon J, Concannon P, Gregersen P K

Abstract excerpt

We propose that the phenomenon of X-chromosome inactivation in females may constitute a risk factor for loss of T-cell tolerance; specifically that skewed X-chromosome inactivation in the thymus may lead to inadequate thymic deletion. Using a DNA methylation assay, we have examined the X-chromosome inactivation patterns in peripheral blood from normal females (n = 30), female patients with a variety of autoimmune...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11056674
DOI: 10.1186/ar118
PMCID: PMC17816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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