Targeted loss of SHP1 in murine thymocytes dampens TCR signaling late in selection.

Abstract excerpt

SHP1 is a tyrosine phosphatase critical to proximal regulation of TCR signaling. Here, analysis of CD4-Cre SHP1(fl/fl) conditional knockout thymocytes using CD53, TCRβ, CD69, CD4, and CD8α expression demonstrates the importance of SHP1 in the survival of post selection (CD53(+) ), single-positive thymocytes. Using Ca(2+) flux to assess the intensity of TCR signaling demonstrated that SHP1 dampens the signal...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gene Targeting
• Share to Histocompatibility Antigens
• Share to Immunophenotyping