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Article

T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool.

Blood - 16 Dec 2010

Smith-Garvin Jennifer E, Burns Jeremy C, Gohil Mercy, Zou Tao, Kim Jiyeon S, Maltzman Jonathan S, Wherry E John, Koretzky Gary A, Jordan Martha S

Abstract excerpt

SH2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) nucleates a signaling complex critical for T-cell receptor (TCR) signal propagation. Mutations in the tyrosines of SLP-76 result in graded defects in TCR-induced signals depending on the tyrosine(s) affected. Here we use 2 strains...

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Topics

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Share to Immunologic Memory
Share to Adaptor Proteins, Signal Transducing
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphocyte Activation

Share to Lymphocytic choriomeningitis virus

Share to Phosphoproteins

Share to Receptors, Antigen, T-Cell

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 20847203
DOI: 10.1182/blood-2010-06-292748
PMCID: PMC3031403

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20847203-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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