Article
The adaptor protein Shc plays a key role during early B cell development.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2009
Giles Amber J, Bender Timothy P, Ravichandran Kodi S
Abstract excerpt
The adaptor protein Shc is phosphorylated downstream of many cell surface receptors, including Ag and cytokine receptors. However, the role of Shc in B cell development has not been addressed. Here, through conditional expression of a dominant negative Shc mutant and conditional loss of Shc protein expression, we tested a role for Shc during early B lymphopoiesis. We identified a requirement for Shc beginning at...
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