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Article

Cutting edge: the tyrosine phosphatase SHP-1 regulates thymocyte positive selection.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 1999

Plas D R, Williams C B, Kersh G J, White L S, White J M, Paust S, Ulyanova T, Allen P M, Thomas M L

Abstract excerpt

The binding kinetics of the TCR for its interacting ligand and the nature of the resulting signal transduction event determine the fate of a developing thymocyte. The intracellular tyrosine phosphatase SHP-1 is a potential regulator of the TCR signal transduction cascade and may affect thymocyte development. To assess the role of SHP-1 in thymocyte development, we generated T cell-transgenic mice that express a...

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PMID: 10229799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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