Article
A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice.
European journal of immunology - 1 Sept 2016
Danzer Claudia, Koller Anna, Baier Julia, Arnold Harald, Giessler Claudia, Opoka Robert, Schmidt Stephanie, Willers Maike, Mihai Sidonia, Parsch Hans, Wirtz Stefan, Daniel Christoph, Reinhold Annegret, Engelmann Swen, Kliche Stefanie, Bogdan Christian, Hoebe Kasper, Mattner Jochen
Abstract excerpt
TCR ligation is critical for the selection, activation, and integrin expression of T lymphocytes. Here, we explored the role of the TCR adaptor protein slp-76 on iNKT-cell biology. Compared to B6 controls, slp-76(ace/ace) mice carrying a missense mutation (Thr428Ile) within the SH2-domain of slp-76 showed an increase in iNKT cells in the thymus and lymph nodes, but a decrease in iNKT cells in spleens and livers,...
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