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Article

Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein.

The Journal of experimental medicine - 18 Oct 1999

Aifantis I, Pivniouk V I, Gärtner F, Feinberg J, Swat W, Alt F W, von Boehmer H, Geha R S

Abstract excerpt

Signaling via the pre-T cell receptor (TCR) is required for the proliferative expansion and maturation of CD4(-)CD8(-) double-negative (DN) thymocytes into CD4(+)CD8(+) double-positive (DP) cells and for TCR-beta allelic exclusion. The adaptor protein SH2 domain-containing leukocyte protein (SLP)-76 has been shown to play a crucial role in thymic development, because thymocytes of SLP-76(-/-) mice are arrested at...

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Identifiers

PMID: 10523607
DOI: 10.1084/jem.190.8.1093
PMCID: PMC2195661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein.PMID 10523607Read ↗

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Allelic exclusion at the TCRbeta locus.Semantic proximity Read ↗

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Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor beta-chain genes.Semantic proximity Read ↗

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Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.Semantic proximity Read ↗

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Receptor-specific allelic exclusion of TCRV alpha-chains during development.Semantic proximity Read ↗

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Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion.Semantic proximity Read ↗

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