Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HPK1 competes with ADAP for SLP‐76 binding and <i>via</i> Rap1 negatively affects T‐cell adhesion

6 Sept 2010

Abstract excerpt

The hematopoietic progenitor kinase 1 (HPK1) signals into MAPK and NFκB pathways downstream of immunoreceptors, but enigmatically is a negative regulator of leukocytes. Here, we report a novel role for HPK1 in regulating the activation of the adhesion molecule leukocyte function-associated antigen-1 (LFA-1). Upon TCR stimulation, mediated by binding of adhesion and degranulation promoting adaptor protein (ADAP)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Galectins and Cancer Biology
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20957749
DOI: 10.1002/eji.201040313

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HPK1 competes with ADAP for SLP‐76 binding and <i>via</i> Rap1 negatively affects T‐cell adhesionPMID 20957749Read ↗

SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesionSemantic proximity Read ↗

The pleckstrin homology domain in the SKAP55 adapter protein defines the ability of the adapter protein ADAP to regulate integrin function and NF-kappaB activation.Semantic proximity Read ↗

Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1.Semantic proximity Read ↗

Deficiency of Rap1-binding protein RAPL causes lymphoproliferative disorders through mislocalization of p27kip1.Semantic proximity Read ↗

Integrin signalling and function in immune cellsSemantic proximity Read ↗

Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes.Semantic proximity Read ↗

Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.Semantic proximity Read ↗

A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice.Semantic proximity Read ↗

Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1.Semantic proximity Read ↗

The Lnk adaptor protein: a key regulator of normal and pathological hematopoiesis.Semantic proximity Read ↗

T cell receptor-induced activation of phospholipase C-gamma1 depends on a sequence-independent function of the P-I region of SLP-76.Semantic proximity Read ↗

KLRG1 binds cadherins and preferentially associates with SHIP-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.