Article
Dual function for the adaptor MIST in IFN-gamma production by NK and CD4+NKT cells regulated by the Src kinase Fgr.
Blood - 1 May 2006
Sasanuma Hiroki, Tatsuno Akiko, Hidano Shinya, Ohshima Keiko, Matsuzaki Yumi, Hayashi Katsuhiko, Lowell Clifford A, Kitamura Daisuke, Goitsuka Ryo
Abstract excerpt
Natural killer (NK) cells and NKT cells play critical early roles in host defense. Here we show that MIST, an adaptor protein belonging to the SLP-76 family, functions negatively in NK cells but positively in CD4(+)NKT cells. NK-cell receptor-mediated IFN-gamma production was enhanced in NK cells...
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