Article
SLAM-associated protein favors the development of iNKT2 over iNKT17 cells.
European journal of immunology - 1 Sept 2016
Michel Marie-Laure, Lenoir Christelle, Massot Bérangère, Diem Séverine, Pasquier Benoit, Sawa Shinichiro, Rignault-Bricard Rachel, Lehuen Agnès, Eberl Gérard, Veillette André, Leite-de-Moraes Maria, Latour Sylvain
Abstract excerpt
Invariant NKT (iNKT) cells differentiate in the thymus into three distinct lineages defined by their cytokine and transcription factor expression. Signaling lymphocyte activation molecule (SLAM)-associated protein (SAP) is essential for early stages of iNKT cell development, but its role during terminal differentiation of iNKT1, iNKT2, or iNKT17 cells remains unclear. Taking advantage of SAP-deficient mice...
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