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Article

PKCδ-targeted intervention relieves chronic pain in a murine sickle cell disease model.

The Journal of clinical investigation - 1 Aug 2016

He Ying, Wilkie Diana J, Nazari Jonathan, Wang Rui, Messing Robert O, DeSimone Joseph, Molokie Robert E, Wang Zaijie Jim

Abstract excerpt

Pain is a life-long symptom in sickle cell disease (SCD) and a predictor of disease progression and mortality, but little is known about its molecular mechanisms. Here, we characterized pain in a targeted knockin mouse model of SCD (TOW mouse) that exclusively expresses human alleles encoding normal α- and sickle β-globin. TOW mice exhibited ongoing spontaneous pain behavior and increased sensitivity to evoked...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27348590
DOI: 10.1172/JCI86165
PMCID: PMC4966317

Genes

SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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