Article
Sensitization of nociceptive spinal neurons contributes to pain in a transgenic model of sickle cell disease.
Pain - 1 Apr 2015
Cataldo Giuseppe, Rajput Sugandha, Gupta Kalpna, Simone Donald A
Abstract excerpt
Chronic pain is a major characteristic feature of sickle cell disease (SCD). The refractory nature of pain and the development of chronic pain syndromes in many patients with SCD suggest that central neural mechanisms contribute to pain in this disease. We used HbSS-BERK sickle mice, which show chronic features of pain similar to those observed in SCD, and determined whether sensitization of nociceptive neurons...
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