Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mast cell activation syndrome as a significant comorbidity in sickle cell disease.

The American journal of the medical sciences - 1 Dec 2014

Afrin Lawrence B

Abstract excerpt

Some sickle cell anemia (SCA) patients suffer significantly worse phenotypes than others. Causes of such disparities are incompletely understood. Comorbid chronic inflammation likely is a factor. Recently, mast cell (MC) activation (creating an inflammatory state) was found to be a significant factor in sickle pathobiology and pain in a murine SCA model. Also, a new realm of relatively noncytoproliferative MC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anemia, Sickle Cell
Share to Caseins
Share to Chromogranin A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heparin

Share to Histamine

Share to Hydroxyurea

Share to Inflammation

Share to Mastocytosis

Source

Open in PubMed Open full text

Identifiers

PMID: 25171546
DOI: 10.1097/MAJ.0000000000000325
PMCID: PMC4242119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mast cell activation syndrome as a significant comorbidity in sickle cell disease.PMID 25171546Read ↗

The Multifaceted Nature of Pain in Sickle Cell Disease: From Molecular Mechanisms to Emerging Therapeutic FrontiersSemantic proximity Read ↗

Sickle cell disease: current clinical management.Semantic proximity Read ↗

Substance P, mast cells and basophils are involved in acute chest syndrome in sickle cell diseaseSemantic proximity Read ↗

Sickle Cell Disease and PainSemantic proximity Read ↗

Widespread Pain Among Youth With Sickle Cell Disease Hospitalized With Vasoocclusive Pain: A Different Clinical Phenotype?Semantic proximity Read ↗

Sickle cell disease patient plasma sensitizes iPSC-derived sensory neurons from sickle cell disease patientsSemantic proximity Read ↗

[Systemic mastocytosis. Classification, symptoms, therapy].Semantic proximity Read ↗

How I Treat Acute Chest Syndrome in Asthmatic Children with Sickle Cell Disease. A Practical Review.Semantic proximity Read ↗

Biomarkers for the diagnosis and phenotyping of acute chest syndrome in patients with sickle cell disease.Semantic proximity Read ↗

A polygenic score for acute vaso-occlusive pain in pediatric sickle cell disease.Semantic proximity Read ↗

An Evaluation of Central Sensitization in Patients With Sickle Cell Disease.Semantic proximity Read ↗

Levels of inflammatory markers are differentially expressed in sickle cell anemia and sickle cell traitSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.