Article
Spatiotemporal Alterations in Gait in Humanized Transgenic Sickle Mice.
Frontiers in immunology - 1 Jan 2020
Kiven Stacy, Wang Ying, Aich Anupam, Argueta Donovan A, Lei Jianxun, Sagi Varun, Tennakoon Madhushan, Bedros Saad J, Lambrecht Nils, Gupta Kalpna
Abstract excerpt
Sickle cell disease (SCD) is a hemoglobinopathy affecting multiple organs and featuring acute and chronic pain. Purkinje cell damage and hyperalgesia have been demonstrated in transgenic sickle mice. Purkinje cells are associated with movement and neural function which may influence pain. We hypothesized that Purkinje cell damage and/or chronic pain burden provoke compensatory gait changes in sickle mice. We...
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