Article

Sickle cell disease patient plasma sensitizes iPSC-derived sensory neurons from sickle cell disease patients

2023-01-10

Abstract excerpt

Individuals living with sickle cell disease (SCD) experience severe recurrent acute and chronic pain. In order to develop novel therapies, it is necessary to better understand the neurobiological mechanisms underlying SCD pain. There are many barriers to gaining mechanistic insight into pathogenic SCD pain processes, such as differential gene expression and function of sensory neurons between humans and mice with...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c29b066e-beb6-5153-a216-99a7df4bbabf
DOI: 10.1101/2023.01.10.523446

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sickle cell disease patient plasma sensitizes iPSC-derived sensory neurons from sickle cell disease patientsDOI 10.1101/2023.01.10.523446Read

The Multifaceted Nature of Pain in Sickle Cell Disease: From Molecular Mechanisms to Emerging Therapeutic FrontiersSemantic proximity Read

Ectopic engraftment of nociceptive neurons derived from hPSCs for pain relief and joint homeostasisSemantic proximity Read

Transcriptomic analysis and high throughput functional characterization of human induced pluripotent stem cell derived sensory neuronsSemantic proximity Read

Derivation and analysis of human somatic sensory neuron subtypes facilitated through fluorescent hPSC reportersSemantic proximity Read

PKCδ-targeted intervention relieves chronic pain in a murine sickle cell disease model.Semantic proximity Read

Spatial transcriptomics reveals unique molecular fingerprints of human nociceptorsSemantic proximity Read

Derivation of nociceptive sensory neurons from hiPSCs with early patterning and temporally controlled NEUROG2 overexpressionSemantic proximity Read

How to differentiate induced pluripotent stem cells into sensory neurons for disease modelling: a comparison of two protocolsSemantic proximity Read

Mast cell activation syndrome as a significant comorbidity in sickle cell disease.Semantic proximity Read

Generation of iPSC-Derived Human Peripheral Sensory Neurons Releasing Substance P Elicited by TRPV1 AgonistsSemantic proximity Read

Selected Ionotropic Receptors and Voltage-Gated Ion Channels: More Functional Competence for Human Induced Pluripotent Stem Cell (iPSC)-Derived NociceptorsSemantic proximity Read

An Evaluation of Central Sensitization in Patients With Sickle Cell Disease.Semantic proximity Read