Article
Casein kinase iδ mutations in familial migraine and advanced sleep phase.
Science translational medicine - 1 May 2013
Brennan K C, Bates Emily A, Shapiro Robert E, Zyuzin Jekaterina, Hallows William C, Huang Yong, Lee Hsien-Yang, Jones Christopher R, Fu Ying-Hui, Charles Andrew C, Ptáček Louis J
Abstract excerpt
Migraine is a common disabling disorder with a significant genetic component, characterized by severe headache and often accompanied by nausea, vomiting, and light sensitivity. We identified two families, each with a distinct missense mutation in the gene encoding casein kinase Iδ (CKIδ), in which the mutation cosegregated with both the presence of migraine and advanced sleep phase. The resulting alterations...
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