Article

The Multifaceted Nature of Pain in Sickle Cell Disease: From Molecular Mechanisms to Emerging Therapeutic Frontiers

2026-05-15

Abstract excerpt

Sickle cell disease (SCD) is an inherited haemoglobinopathy resulting from a single point mutation in the β-globin gene, leading to the polymerization of deoxygenated haemoglobin and the formation of sickled erythrocytes. This multisystem disorder is characterized by recurrent acute and chronic pain, which remains its most common and debilitating complication, significantly impacting morbidity, mortality, and qual...

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Literature Corpus work: d545e4c8-4530-582f-87ae-44e9ea02b5f7
DOI: 10.32388/uh2l2u

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