Article
A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene.
Cell - 12 Nov 2010
Neely G Gregory, Hess Andreas, Costigan Michael, Keene Alex C, Goulas Spyros, Langeslag Michiel, Griffin Robert S, Belfer Inna, Dai Feng, Smith Shad B, Diatchenko Luda, Gupta Vaijayanti, Xia Cui-Ping, Amann Sabina, Kreitz Silke, Heindl-Erdmann Cornelia, Wolz Susanne, Ly Cindy V, Arora Suchir, Sarangi Rinku, Dan Debasis, Novatchkova Maria, Rosenzweig Mark, Gibson Dustin G, Truong Darwin, Schramek Daniel, Zoranovic Tamara, Cronin Shane J F, Angjeli Belinda, Brune Kay, Dietzl Georg, Maixner William, Meixner Arabella, Thomas Winston, Pospisilik J Andrew, Alenius Mattias, Kress Michaela, Subramaniam Sai, Garrity Paul A, Bellen Hugo J, Woolf Clifford J, Penninger Josef M
Abstract excerpt
Worldwide, acute, and chronic pain affects 20% of the adult population and represents an enormous financial and emotional burden. Using genome-wide neuronal-specific RNAi knockdown in Drosophila, we report a global screen for an innate behavior and identify hundreds of genes implicated in heat nociception, including the α2δ family calcium channel subunit straightjacket (stj). Mice mutant for the stj ortholog...
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