Article
Detection of Hot-Spot Mutations in Circulating Cell-Free DNA From Patients With Intraductal Papillary Mucinous Neoplasms of the Pancreas.
Gastroenterology - 1 Aug 2016
Berger Andreas W, Schwerdel Daniel, Costa Ivan G, Hackert Thilo, Strobel Oliver, Lam Sandra, Barth Thomas F, Schröppel Bernd, Meining Alexander, Büchler Markus W, Zenke Martin, Hermann Patrick C, Seufferlein Thomas, Kleger Alexander
Abstract excerpt
Intraductal papillary mucinous neoplasms (IPMNs) are the most frequent cystic pancreatic tumors. Little is known about their molecular alterations, but mutations in GNAS have been reported to promote IPMN formation. A tumor-derived fraction of circulating cell-free DNA (cfDNA), isolated from blood samples, contains many of the same mutations as the primary tumor, and could be a tool for noninvasive disease...
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