Circulating Cell-Free DNA fragmentomics distinguishes pancreatic ductal adenocarcinoma from non- malignant conditions

Abstract excerpt

<title>Abstract</title> <p>Purpose Pancreatic ductal adenocarcinoma (PDAC) has poor survival rates due to late diagnosis and limited early detection methods. Existing serum biomarkers have inadequate sensitivity and specificity. This study assessed whether circulating cell-free DNA (cfDNA) fragmentomic features could distinguish PDAC from chronic pancreatitis (CP) and healthy controls. Methods In this prospecti...

Topics

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• Adenocarcinoma
• Biomarkers, Tumor
• Cell-Free Nucleic Acids
• Circulating Tumor DNA
• High-Throughput Nucleotide Sequencing
• Pancreatic Neoplasms
• Proto-Oncogene Proteins p21(ras)
• Tumor Suppressor Protein p53

Identifiers and source

Literature Corpus work

5b6d3691-bc5d-5ee2-ac81-ede5219be0c6

DOI

10.21203/rs.3.rs-10015052/v1