Article
Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer.
Cancer biology & therapy - 4 Mar 2017
Yang Sujuan, Che Sara P Y, Kurywchak Paul, Tavormina Jena L, Gansmo Liv B, Correa de Sampaio Pedro, Tachezy Michael, Bockhorn Maximilian, Gebauer Florian, Haltom Amanda R, Melo Sonia A, LeBleu Valerie S, Kalluri Raghu
Abstract excerpt
Pancreatic cancer presents with a dismal mortality rate and is in urgent need of methods for early detection with potential for timely intervention. All living cells, including cancer cells, generate exosomes. We previously discovered double stranded genomic DNA in exosomes derived from the circulation of pancreatic cancer patients, which enabled the detection of prevalent mutations associated with the disease....
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