Article
Cell-Free DNA Next-Generation Sequencing in Pancreatobiliary Carcinomas.
Cancer discovery - 1 Oct 2015
Zill Oliver A, Greene Claire, Sebisanovic Dragan, Siew Lai Mun, Leng Jim, Vu Mary, Hendifar Andrew E, Wang Zhen, Atreya Chloe E, Kelley Robin K, Van Loon Katherine, Ko Andrew H, Tempero Margaret A, Bivona Trever G, Munster Pamela N, Talasaz AmirAli, Collisson Eric A
Abstract excerpt
UNLABELLED: Patients with pancreatic and biliary carcinomas lack personalized treatment options, in part because biopsies are often inadequate for molecular characterization. Cell-free DNA (cfDNA) sequencing may enable a precision oncology approach in this setting. We attempted to prospectively analyze 54 genes in tumor and cfDNA for 26 patients. Tumor sequencing failed in 9 patients (35%). In the remaining 17,...
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