Article
Digital PCR-based plasma cell-free DNA mutation analysis for early-stage pancreatic tumor diagnosis and surveillance.
Journal of gastroenterology - 1 Dec 2020
Okada Tetsuhiro, Mizukami Yusuke, Ono Yusuke, Sato Hiroki, Hayashi Akihiro, Kawabata Hidemasa, Koizumi Kazuya, Masuda Sakue, Teshima Shinichi, Takahashi Kuniyuki, Katanuma Akio, Omori Yuko, Iwano Hirotoshi, Yamada Masataka, Yokochi Tomoki, Asahara Shingo, Kawakubo Kazumichi, Kuwatani Masaki, Sakamoto Naoya, Enomoto Katsuro, Goto Takuma, Sasajima Junpei, Fujiya Mikihiro, Ueda Jun, Matsumoto Seiji, Taniue Kenzui, Sugitani Ayumu, Karasaki Hidenori, Okumura Toshikatsu
Abstract excerpt
BACKGROUND: Cell-free DNA (cfDNA) shed from tumors into the circulation offers a tool for cancer detection. Here, we evaluated the feasibility of cfDNA measurement and utility of digital PCR (dPCR)-based assays, which reduce subsampling error, for diagnosing pancreatic ductal adenocarcinoma (PDA) and surveillance of intraductal papillary mucinous neoplasm (IPMN). METHODS: We collected plasma from seven...
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