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Article

Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis.

Proceedings of the National Academy of Sciences of the United States of America - 12 Jul 2016

Tokumasu Reitaro, Yamaga Kosuke, Yamazaki Yuji, Murota Hiroyuki, Suzuki Koya, Tamura Atsushi, Bando Kana, Furuta Yasuhide, Katayama Ichiro, Tsukita Sachiko

Abstract excerpt

Atopic dermatitis (AD) is a chronic inflammatory skin disease in humans. It was recently noted that the characteristics of epidermal barrier functions critically influence the pathological features of AD. Evidence suggests that claudin-1 (CLDN1), a major component of tight junctions (TJs) in the epidermis, plays a key role in human AD, but the mechanism underlying this role is poorly understood. One of the main...

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Identifiers

PMID: 27342862
DOI: 10.1073/pnas.1525474113
PMCID: PMC4948351

Genes

CLDN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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