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Article

Claudin-1 decrease impacts epidermal barrier function in atopic dermatitis lesions dose-dependently

6 Feb 2020

Abstract excerpt

The transmembrane protein claudin-1 is a major component of epidermal tight junctions (TJs), which create a dynamic paracellular barrier in the epidermis. Claudin-1 downregulation has been linked to atopic dermatitis (AD) pathogenesis but variable levels of claudin-1 have also been observed in healthy skin. To elucidate the impact of different levels of claudin-1 in healthy and diseased skin we determined...

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PMID: 32029783
DOI: 10.1038/s41598-020-58718-9

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