Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Scratching damages tight junctions through the Akt–claudin 1 axis in atopic dermatitis

15 Jul 2020

Abstract excerpt

BACKGROUND: Atopic dermatitis (AD) is a common, chronic, severely pruritic, eczematous skin disease that seriously deteriorates the quality of life of patients. Scratching is a cardinal symptom of AD. Although the vicious itch-scratch cycle continues and aggravates skin barrier dysfunction in AD, how scratching induces skin barrier dysfunction through tight junctions remains unclear. AIM: To study the effect of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Barrier Structure and Function Studies
Share to Connexins and lens biology
Share to Dermatology and Skin Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32668051
DOI: 10.1111/ced.14380

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Scratching damages tight junctions through the Akt–claudin 1 axis in atopic dermatitisPMID 32668051Read ↗

Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis.Semantic proximity Read ↗

Scratching promotes allergic inflammation and host defense via neurogenic mast cell activationSemantic proximity Read ↗

Claudin-1 decrease impacts epidermal barrier function in atopic dermatitis lesions dose-dependentlySemantic proximity Read ↗

Diverse Regulation of Claudin-1 and Claudin-4 in Atopic DermatitisSemantic proximity Read ↗

Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17Semantic proximity Read ↗

Neuronal STING drives neuroimmune circuits underlying atopic itchSemantic proximity Read ↗

Tight junction defects in patients with atopic dermatitis.Semantic proximity Read ↗

Increased expression of Filaggrin and Claudin-1 in the ocular surface of patients with atopic dermatitis.Semantic proximity Read ↗

CFTR-deficiency renders mice highly susceptible to cutaneous symptoms during mite infestation.Semantic proximity Read ↗

The itch-scratch reflex generates protective immunitySemantic proximity Read ↗

Glycogen synthase kinase 3beta and beta-catenin are involved in the injury and repair of bronchial epithelial cells induced by scratching.Semantic proximity Read ↗

Scratching Responses to Epidermal Injury in C57BL/6, DBA/2, BALB/c, and CD1 Mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.