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Article

CLDN1 knock out keratinocytes as a model to investigate multiple skin disorders

1 May 2024

Abstract excerpt

The transmembrane protein claudin-1 is critical for formation of the epidermal barrier structure called tight junctions (TJ) and has been shown to be important in multiple disease states. These include neonatal ichthyosis and sclerosing cholangitis syndrome, atopic dermatitis and various viral infections. To develop a model to investigate the role of claudin-1 in different disease settings, we used CRISPR/Cas9 to...

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PMID: 38711223
DOI: 10.1111/exd.15084

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