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Article

The tight junction gene Claudin-1 is associated with atopic dermatitis among Ethiopians.

Journal of the European Academy of Dermatology and Venereology : JEADV - 1 Nov 2016

Asad S, Winge M C G, Wahlgren C-F, Bilcha K D, Nordenskjöld M, Taylan F, Bradley M

Abstract excerpt

BACKGROUND: The strong association between epidermal barrier gene variants and Atopic Dermatitis (AD) highlights that impaired skin barrier is a key feature in the pathogenesis of AD. Although the filaggrin (FLG) gene is the major AD risk gene in European and Asian populations, disease-associated variants remain elusive in African populations. OBJECTIVE: A previous study has reported that variants in the tight...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27581203
DOI: 10.1111/jdv.13806

Genes

CLDN1
FLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The tight junction gene Claudin-1 is associated with atopic dermatitis among Ethiopians.PMID 27581203Read ↗

Tight junction defects in patients with atopic dermatitis.Semantic proximity Read ↗

Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis.Semantic proximity Read ↗

Novel filaggrin mutation but no other loss-of-function variants found in Ethiopian patients with atopic dermatitis.Semantic proximity Read ↗

Association of epidermal differentiation complex (EDC) genetic variants with House Dust Mite sensitization in Atopic Dermatitis Patients.Semantic proximity Read ↗

Claudin-1 decrease impacts epidermal barrier function in atopic dermatitis lesions dose-dependentlySemantic proximity Read ↗

Unlocking Ethiopia's genomic landscape and its global significance: a call for inclusive genomics research.Semantic proximity Read ↗

Diverse Regulation of Claudin-1 and Claudin-4 in Atopic DermatitisSemantic proximity Read ↗

Intragenic Copy Number Variation in the Filaggrin Gene in Ethiopian Patients with Atopic Dermatitis.Semantic proximity Read ↗

Increased expression of Filaggrin and Claudin-1 in the ocular surface of patients with atopic dermatitis.Semantic proximity Read ↗

Keratin 76 Is Required for Tight Junction Function and Maintenance of the Skin BarrierSemantic proximity Read ↗

Genetic variation in the epidermal transglutaminase genes is not associated with atopic dermatitis.Semantic proximity Read ↗

Scratching damages tight junctions through the Akt–claudin 1 axis in atopic dermatitisSemantic proximity Read ↗

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